6 edition of Genetic effects on aging found in the catalog.
Includes bibliographical references and index.
|Statement||sponsored by the National Foundation - March of Dimes ; editors, Daniel Bergsma, David E. Harrison ; associate editor, Natalie W. Paul.|
|Series||Birth defects original article series ;, v. 14 no. 1|
|Contributions||Bergsma, Daniel., Harrison, David E., 1942-, Paul, Natalie W.|
|LC Classifications||RG626 .B63 vol. 14, no. 1, QP86 .B63 vol. 14, no. 1|
|The Physical Object|
|Pagination||xiv, 536 p. :|
|Number of Pages||536|
|LC Control Number||77020249|
So far, we do not really understand the mechanisms behind the magnification of genetic effects with aging. The question is whether lower brain resources per se lead to increased genetic effects in old age. Alternatively, the stronger genetic effects could be mediated through lifestyle factors that may influence the expression of a gene. The Biology of Aging: An Overview Robert J. Pignolo, M.D., Ph.D. • Subsets of aging features in human geneticSubsets of aging features in human genetic syndromes of premature aging. negati ff t l t i liftive effects later in life.
The genetic differences that have the most dramatic impact on the rate of aging—those that slow aging more in dogs than in mice and still more in humans and whales—are impervious to the traditional methods of genetics, which focus on analysis of Cited by: Aging is accompanied by gradual changes in most body systems. Research on the biology of aging focuses on understanding the cellular and molecular processes underlying these changes as well as those accompanying the onset of age-related diseases. As scientists learn more about these processes, experiments can be designed to better understand when and how pathological changes begin, .
Mothers’ genes also play a vital part in determining how fast their children grow old by passing on genetic mutations that speed up the aging process, according to a study. Scientists at. Aging and death are, of course, inevitable, but despite the progress decline in function associated with aging, many elderly individuals remain cognitively sharp and physically active. This section explores lifestyle choices that appear to be associated with increased longevity and enhanced quality of life in older individuals.
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Genetic Theory of Aging. The genetic theory of aging states that lifespan is largely determined by the genes we inherit. According to the theory, our longevity is primarily determined at the moment of conception and is largely reliant on our parents and their genes.
. ISBN: OCLC Number: Description: xii, pages: illustrations ; 24 cm: Other Titles: Genetic effects on aging 2. Genetic effects. Genetic Effects on Aging (Telford Press) II: Medicine & Health Science Books @ ed by: The Genetics of Aging is divided into several sections in an attempt to provide a logical progression from the level of the genome to the realm of human genetics.
The relationship between the genetic material and aging will be thoroughly explored in the initial chapters. These chapters discuss in depth the various theories that have been 5/5(1).
Aging, healthy aging, and longevity. The phenotypes used in studies of the genetics of human aging are usually lifespan (age at death), longevity (long life, usually defined as being a specific advanced age or older at the time of study), exceptional longevity (defined as attaining or exceeding a specific exceptional age), or healthy aging (a combination of old age and health, often defined as Cited by: Genetics of aging is generally concerned with life extension associated with genetic alterations, rather than with accelerated aging diseases leading to reduction in lifespan.
The first mutation found to increase longevity in an animal was the age-1 gene in Caenorhabditis l Klass discovered that lifespan of C. elegans could be altered by mutations, but Klass believed that the.
The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses.
Aging is influenced by many intrinsic and extrinsic factors including genetic background, epigenetics, diet, and environment. Our ability to develop a complete model of the aging process and accurately predict outcomes designed to extend lifespan or treat age-associated pathology requires identification of the range of factors capable of influence aging and an understanding of how these.
Genetic effects on aging: proceedings of a conference held at the Jackson Laboratory, September The role of genetics in determining life-span is complex and paradoxical. Although the heritability of life-span is relatively minor, some genetic variants significantly modify senescence of mammals and invertebrates, with both positive and negative impacts on age-related disorders and life-spans.
In certain examples, the gene variants alter metabolic pathways, which could thereby mediate Cited by: Screening for coordinated age regulation of genetic pathways increases the sensitivity of the analysis, as the combined effects of small regulation of many genes in a pathway can be significant.
This systems biology method is especially powerful in studies of ageing because of the polygenic nature of the by: Turning off 'aging genes' Date: states and predict the environmental or genetic changes required to go from one state to the other. fasting or calorie restriction has anti-aging effects on.
Genetic influence on aging into the 90s but not beyond Date: J Source: Oregon State University Summary: Variants of a gene thought to be linked to longevity appear to influence aging. Scope Probing the genetic and molecular bases of aging and aging-related processes in humans and in animal models, Genetics of Aging is a multidisciplinary section publishing research on age-related changes in gene expression, signaling, cell proliferation, cell death, stress responses, and senescence; the genes implicated in age-related diseases and impairment; and the role of stem cells in.
Criteria are needed to relate the differential genetic effects on survival and individual aging. We propose a general definition of aging, based on its common denominator, that is valid for the organism and the cell.
We argue that aging is discontinuous and occurs in discrete by: 1. In this brief review of selected genetical aspects of aging, I make a strong argument for the importance of an evolutionary perspective as a guide to genetic analysis. The current consensus regarding the nonadaptive nature of aging and the emphasis upon the theories of antagonistic pleiotropy and mutation accumulation have major implications Author: G.
Martin. The process of aging refers to the decay of an organism's structure and function, in which molecular and cellular modifications can have various effects at the individual level over the course of.
This PA is framed around two broad categories of questions: (1) gene-to-behavior questions concerning the nature and role of genetic influences on behaviors at older ages, and how these genetic effects vary with age; and (2) questions about dynamic processes including gene-environment interactions, gene-environment covariation, age-related.
The new study, according to Weindruch, is important not only because it provides a genetic map of aging, but because it shows the potential of harnessing gene chip technology to screen for the effects of drugs on the process of growing old.
“It gives us a molecular test to. The purpose of this book is threefold: first, to inform researchers and clinicians in gerontology about the behavioral genetic perspective; second, to present an overview of what is known about genetic and environmental influences on behavioral aging; and, finally, to stimulate future work in this field by discussing what is not yet known but.
This, in turn, means that genetic mutations having detrimental effects that are only felt late in life may persist in a population. Although widely accepted, this theory rests on the assumption that there is genetic variation for aging in natural systems.variable penetrance of genetic risk factors that appear to affect survival and health at advanced ages, life-style and other environmental influences may profoundly modify outcomes of aging.
THE aging process, at least in lower organisms, appears to be affected by several biochemical pathways, including insulin and insulin-like growth factor 1 (IGF1) signaling (1,2), growth hormone (), oxidative damage, and lipids ().In addition, maintenance and repair of DNA (), including mitochondrial DNA (), has proved l of apoptosis and cell senescence (7,8), often in Cited by: